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Pharma - Engineering - Plastic plasma processing columns

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Stichting Sanquin Bloedvoorziening

Stichting Sanquin Bloedvoorziening is a Dutch non-profit organisation that handles the supply of blood and blood products in the Netherlands. The modern Plasma Products division is part of Sanquin Bloedvoorziening. It makes medicines from human blood plasma for the treatment of a range of diseases, including clotting agents, immunoglobulines and albumine, for the Dutch and international market.

Scaling up columns

Certain clotting agents are distilled from the plasma with what is known as a 3F column and a 4F column. A PEG filtration column is used for filtrations. To handle growing market demand and work more efficiently required bigger columns. They had to be scaled up from 1600 kilograms of plasma per batch to 2500. The PEG filtration column had to be expanded from 800 to 2500 kilograms. The plastic basins in which the columns could be cleaned were also to be modified.

Calculations and desings

Capacity increase was realized through a linear scale-up of three plasma processing columns. Although the scaling-up was linear, it still posed engineering challenges. ERIKS dealt with all the calculations and designs.

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Expertise

The design had a flaw that both parties had overlooked. The 3F and 4F columns are fixed with bolts and nuts. For the PEG filtration column we also had to put in big toggles, but then we found that we couldn’t fill the columns anymore. They turned out to be totally different systems. Whatever the challenges, ERIKS always solved them in consultation with the customer.

The customer was very satisfied about the collaboration and the expertise of ERIKS. New designs and calculations, the supply of the right FDA and USP certificates, everything was handled promptly.

Click here to download a pdf of this case study. (213kB)

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